|
KMID : 1123920030170030765
|
|
Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 3 p.765 ~ p.770
|
|
|
Study on Antitumor Activity of Kamibojungikgi-tang
|
|
Lee Byung-Ju
Kim Dong-Hee
Lee Hyo-Jeong
Kim Sung-Hoon
|
|
|
Abstract
|
|
|
|
To explore the possible cancer agent from oriental prescriptions, we have examined its antitumor and anti metastatic activities of Kamibojungikgi-tang(KBIT). KBIT extracts exhibited cytotoxicity against P388, A549 and B16-F10 cell lines in a dose-dependent manner and showed antiadhesive effect of A549 cell to complex extracellular matrix at 1 ㎎/㎖ in vitro. In DNA topoisomerase I assay, KBIT extracts showed strong inhibitoty effect in a dose-dependent manner. In pulmonary colonization assay with B16BL6, a number of colonies in the lungs were decreased effectively in KBIT treated group as compared with control group. Moreover, in CAM assay, KBIT extracts significantly inhibited angiogenesis at 15㎍/egg as compared with control. The T/C% was 141% in KBIT treated group in S-180 bearing ICR mice. From the above results it was concluded that KBIT had antitumor and anti metastatic activities. So it is expected to be clinically helpful on the prevention and treatment of cancer, although it is still necessary to study its mechanism on molecular biology and immunology.
|
|
|
KEYWORD
|
|
|
Kamibojungikgi-tang(加味補中益氣湯), cytotoxicity, pulmonary colonization, anti adhesion, DNA toposiomerase I, S-180, CAM assay
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|